Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

By Lu Chen, D. Chetkovich, R. Petralia, Neal T. Sweeney, Y. Kawasaki, R. Wenthold, D. Bredt, R. Nicoll. Nature, 2000

1,113 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/78b778d46181a21f7a8a93cfb414904ad32bae14

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Malenka
2. Richard L. Huganir
3. R. Nicoll
4. A. Citri
5. M. Sheng
6. N. J. Allen
7. Gina G. Turrigiano
8. R. Malinow

In Molecular Biology

1. R. Malenka
2. R. Nicoll
3. Richard L. Huganir
4. A. Citri
5. M. Sheng
6. Clifford J. Woolf
7. R. Malinow
8. J. Shepherd

In Neurology

1. B. Barres
2. N. J. Allen
3. R. Nicoll
4. Richard L. Huganir
5. A. Citri
6. M. Sheng
7. R. Malenka
8. C. Lüscher

Citations in the corpus

• Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. (2003, background): “PSD-95 also binds to stargazin,Cambridge, Massachusetts 02139 a protein that escorts AMPA receptors to the synapse (Chen et al., 2000; Schnell et al., 2002).”
• The molecular basis of CaMKII function in synaptic and behavioural memory (2002, background): “First, transfection of cultured cells with a form of the protein STARGAZIN that is defective in PDZ interactions produces a marked reduction in synaptic glutamate receptors without affecting extrasynaptic receptor”
• Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “TARPs are required for the delivery of AMPARs to the plasma membrane at extrasynaptic sites (Chen et al, 2000; Nicoll et al, 2006) and also influence their biophysical properties (Tomita et al, 2005a).”
• PDZ domain proteins of synapses (2004, background): “Stargazin and its relatives are essential for the surface expression and synaptic accumulation of AMPARs, and the latter activity depends on an interaction of the stargazin C terminus with the PDZ domains of PSD-95 (Ref”
• α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis (2003, neutral): “The neurexin hypothesis Marked advances have been made recently in the understanding of postsynaptic mechanisms, for example the discovery of stargazins and the molecular description of glutamate receptor recyclin”
• TARP γ-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity (2005, positive): “, controls the synaptic targeting and functioning of AMPARs in cerebellar granule cells by multiple mechanism”
• Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity (2009, positive): “but is instead highly concentrated in the PSD and co-immunoprecipitates with GluR1, 2, and 4.(43,335) The protein is a major AMPAR partner, along with the 4 other isoforms, g3, g4, g7, and g8,(140,335) which form the TARP subgroup.”
• AMPA receptor trafficking and synaptic plasticity. (2002, background): “Animals without the transmembrane protein STG lack AMPAR responses in granule cells of the cerebellum (Hashimoto et al. 1999).”
• The cell biology of synaptic plasticity: AMPA receptor trafficking. (2007, background): “This interaction between the TARPs and PSD-95 appears to be crucial for AMPAR targeting to synapses (Chen et al. 2000, Tomita et al. 2005).”
• Molecular physiology of cardiac repolarization. (2005, background): “Interestingly, it has also been reported that Cav 2 interacts with the AMPA subtype of neuronal glutamate receptors, suggesting that the Cav -subunits may, like other channel accessory subunits, be multifunctional proteins (96).”