Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases.

By P. Low, W. Henne, D. D. Doorneweerd. Accounts of Chemical Research, 2008

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Insight into nanoparticle cellular uptake and intracellular targeting (2014, positive): “allows the selective delivery of folate-conjugated nanocarriers to the FR-expressing disease cells [97].”
Current trends in the use of liposomes for tumor targeting (2013, background): “Folate-linked nanoparticles deliver their cargo intracellularly through receptor-mediated endocytosis [25,26].”
The delivery of therapeutic oligonucleotides (2016, background): “The folate receptor is believed to be upregulated in many types of cancer cells and folate has been extensively used as a targeting ligand for drugs and nanoparticles (307).”
Nanomedicine in cancer therapy (2023, background): “FA binds with high affinity and specificity to folate receptors (FR) that are extraordinarily overexpressed on the surface of various carcinomas, including ovarian, renal, lung, pancreatic, breast, and brain cancers, exhibiting levels that are 100 to 300 times greater compared to those found in norm”