Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

By Ran He, Shiyue Hou, Cheng Liu, A. Zhang, Qiang Bai, M. Han, Yu Yang, Gang Wei, T. Shen, Xinxin Yang and 17 more. Nature, 2016

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Subfields: Immunology

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T Cell Dysfunction in Cancer (2018, background): “CD28, among other costimulatory molecules such as ICOS, is also expressed on the LCMV-specific CXCR5+ PD-1int T cells that mediate response to PD-1 therapy in mouse models (Im et al., 2016).”
Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade (2016, neutral): “In particular, the TEX population appears heterogeneous in TCIR expression, exhaustion-related markers, and reinvigoration potential (Blackburn et al., 2008; He et al., 2016; Im et al., 2016; Utzschneider et al., 2016).”
T follicular helper cell biology: A decade of discovery and diseases (2019, background): “Id2 inhibits CXCR5+ CD8 T cell development (He et al., 2016b; Leong et al., 2016), and Id2 inhibits Tfh differentiation (Shaw et al., 2016).”
Mechanisms of resistance to immune checkpoint inhibitors (2018, background): “…in response to PD-1/PD-L1 blockade identified a unique subset of CD8þPD-1þ T cells that share features of T-follicular helper cells, CD8 memory precursors, and stem cells (Im et al, 2016), and resemble CXCR5þ CD8þ follicular T cells (He et al, 2016; Leong et al, 2016; Utzschneider et al, 2016).”