Protein Composition of Catalytically Active Human Telomerase from Immortal Cells

By Scott B. Cohen, M. Graham, G. Lovrecz, N. Bache, P. Robinson, R. Reddel. Science, 2007

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Telomeres and aging. (2008, background): “The ribonucleoprotein dyskerin (encoded by the DKC1 gene on the X chromosome) is required for proper folding and stability of telomerase RNA (228) and was recently found to be part of the basic human telomerase enzyme complex (45).”
How shelterin protects mammalian telomeres. (2008, background): “Consistent with previous reports on the low abundance of telomerase components (206), it was recently documented that human HEK-293 cells contain on average only 20–50 molecules of active telomerase (34).”
Telomere length, stem cells and aging. (2007, background): “A recent study with highly purified telomerase extracts has demonstrated that the telomerase enzyme contains two molecules each of the telomerase reverse transcriptase subunit (Tert) and the telomerase-associated RNA molecule (Terc), as well as one molecule of dyskeri”
Advance Publication by J-STAGE Japanese Journal of Infectious Diseases Isolation of human coronaviruses OC43, HKU1, NL63, and 229E in Yamagata, Japan, using primary human airway epithelium cells cultured by employing an air-liquid interface culture (2020, positive): “Telomerase consists of two main subunits: TERT and the telomerase RNA component (TERC) [39] (Fig.”
Telomerase and cancer therapeutics (2008, background): “Even in a telomerase-positive tumour cell, the abundance of the enzyme is only about 100 molecules per cel”