DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

By Keith D. Robertson, S. Ait-Si-Ali, T. Yokochi, P. Wade, P. Jones, A. Wolffe. Nature Genetics, 2000

997 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/782285ff396c4fd81c03c3e96875050acd1b9aac

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Citations in the corpus

The role of histone deacetylases (HDACs) in human cancer (2007, background): “Focusing on the interaction with transcription factors, HDAC1 and HDAC2 are involved in transcriptional repression regulated by the retinoblastoma protein Rb (Robertson et al., 2000).”
DNA methylation patterns and epigenetic memory. (2002, background): “The nature of the molecular cues that trigger transfer of methyl groups to unmethylated DNA should be illuminated by ongoing studies of multiprotein complexes that contain DNA methyltransferases (Fuks et al. 2000, 2001; Robertson et al. 2000; Bachman et al. 2001) and the identification of genes that”
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future (2002, background): “The last piece in the epigenetic jigsaw is provided by the finding that the DNA methyltransferases themselves are also associated with HDAC activities (Fuks et al., 2000; Robertson et al., 2000).”
Transient Low Doses of DNA Demethylating Agents Exert Durable Anti-tumor Effects on Hematological and Epithelial Tumor Cells (2012, background): “Also, all the DNMTs assuredly participate in complex protein interactions where they may exert scaffolding functions with effects on other chromatin regulatory features (Robertson et al., 2000; Rountree et al., 2000).”
Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. (2002, positive): “The basic tenets of the maintenance (Robertson et al., 2000; Rountree et al., 2000).”
Epigenetic Determinants of Cancer. (2016, background): “This protein loss is potentially very important for the DNMT inhibitors to achieve reexpression of key cancer genes because, experimentally, all three biologically active DNMTs can exert transcriptional repression independent of catalyzing DNA methylation (Fuks et al. 2000; Robertson et al. 2000; Ro”