TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2.

By Wei-Man Wang, G. Ge, Nh H. Lim, Hideaki Nagase, D. Greenspan. 2006

103 citations recorded by the source corpus.

Subfields: Biotechnology, Cancer Research, Urology

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In Cancer Research

1. R. Khalil
2. Gillian Murphy
3. Hideaki Nagase
4. S. Zhong
5. D. Edwards
6. K. Brew
7. A. Colige
8. M. Bekhouche

Citations in the corpus

• A Disintegrin and Metalloproteinase (ADAM) and ADAM with Thrombospondin Motifs (ADAMTS) Family in Vascular Biology and Disease (2019, background): “Ren P, Hughes M, Krishnamoorthy S, Zou S, Zhang L, Wu D, et al. Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.”
• Cellular and molecular mechanisms in kidney fibrosis. (2014, unknown): “Recent studies have identified ADAMTS-2 as a highly upregulated gene in FOXD1-lineage cells when they become myofibroblasts, while its endogenous inhibitor TIMP-3 is highly downregulated (42, 99, 100).”
• The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family (2015, background): “Once again, versican heterozygosity exacerbated the phenotype seen with mice deficient in ADAMTS20 Table 1 ADAMTS genes: their chromosomal positions, major tissue expression locations, expression-inducing factors bstrates, and associations with pathologies Gene Location Expression Factors inducing o”
• ADAMs family and relatives in cardiovascular physiology and pathology. (2016, background): “TIMP3 has been identified as the most potent inhibitor for ADAM-TS2 [116] and ADAM-TS4 [117].”
• The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology. (2015, background): “TIMP3 has also been shown to inhibit the aminopropeptide cleavage of type I, II and III collagen when added in excess in the presence of heparin [21] However, TIMP3 is a wide-spectrum inhibitor with activities towards several MMPs, ADAMs and ADAMTSs [22].”
• The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity (2010, background): “N-TIMP-3 is a weak inhibitor of ADAMTS-2, procollagen N-proteinase, with a Ki of about 600 nM, but the inhibition is also enhanced by heparin to a Ki of 160 nM [26].”
• Progress in matrix metalloproteinase research. (2008, background): “, 1999) and ADAMTSs (ADAMTS-1, -2, -4 and -5) (Kashiwagi et al., 2001; Rodriguez-Manzaneque et al., 2002; Wang et al., 2006).”