Dynamic T cell migration program provides resident memory within intestinal epithelium

By D. Masopust, Daniel K. Choo, V. Vezys, E. Wherry, Jaikumar Duraiswamy, Rama S. Akondy, Jun Wang, K. Casey, Daniel L. Barber, K. Kawamura and 6 more. Journal of Experimental Medicine, 2010

618 citations recorded by the source corpus.

Migration to intestinal mucosa putatively depends on local activation because gastrointestinal lymphoid tissue induces expression of intestinal homing molecules, whereas skin-draining lymph nodes do not. This paradigm is difficult to reconcile with reports of intestinal T cell responses after alternative routes of immunization. We reconcile this discrepancy by demonstrating that activation within spleen results in intermediate induction of homing potential to the intestinal mucosa. We further demonstrate that memory T cells within small intestine epithelium do not routinely recirculate with memory T cells in other tissues, and we provide evidence that homing is similarly dynamic in humans after subcutaneous live yellow fever vaccine immunization. These data explain why systemic immunization routes induce local cell-mediated immunity within the intestine and indicate that this tissue must be seeded with memory T cell precursors shortly after activation.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/7740c364d8ea167f5ba638895c4bd90e45cbeed9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Tissue-Resident Memory T Cells (2014, background): “After acute viral infections in mice and humans, effector T cells transiently upregulate a4b7 integrin, which facilitates migration into the small intestine (Campbell and Butcher, 2002; Liu et al., 2006; Masopust et al., 2010).”
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity (2012, background): “T RM cells have now been identified in the skin, gut, lung and brain in murine model”
Antigen independent differentiation and maintenance of effector-like resident memory T cells in tissues (2012, background): “5 through day 7), after which they become resident with minimal evidence for recirculation (13).”
From Vaccines to Memory and Back (2010, neutral): “A recent study has provided a potential explanation for these observations by showing that priming of CD8 T cells in the spleen results in a promiscuous homing program that can drive cells to the intestinal mucosa (Masopust et al., 2010).”
Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation (2012, background): “On transition into memory and in the absence of persisting antigen, T cells lose expression of homing molecules and chemokine receptors that drive extravasation and tissue infiltration (17, 18, 36).”
Transcriptional downregulation of S1pr1 is required for establishment of resident memory CD8+ T cells (2013, background): “Furthermore, IL-2-induced downregulation of KLF2 expression is dependent on activation of the PI(3)K–Akt pathway37.”