The infant airway microbiome in health and disease impacts later asthma development
By S. Teo, D. Mok, K. Pham, M. Kusel, M. Serralha, N. Troy, B. Holt, B. Hales, Michael L. Walker, E. Hollams and 8 more. Cell Host and Microbe, 2015
849 citations recorded by the source corpus.
The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory illnesses (ARI). The development of asthma is initiated during infancy, driven by airway inflammation associated with infections. Here, we report viral and bacterial community profiling of NP aspirates across a birth cohort, capturing all lower respiratory illnesses during their first year. Most infants were initially colonized with Staphylococcus or Corynebacterium before stable colonization with Alloiococcus or Moraxella, with transient incursions of Streptococcus, Moraxella or Haemophilus marking virus-associated ARIs. Our data identify the NP microbiome as a determinant for infection spread to the lower airways, severity of accompanying inflammatory symptoms, and risk for future asthma development. Early asymptomatic colonization with Streptococcus was a strong asthma predictor, and antibiotic usage disrupted asymptomatic colonization patterns.
Subfields: Emergency Medical Services, Epidemiology, Pharmacy
View Paper: https://www.semanticscholar.org/paper/77005fbd5736c2ee4bc3eac4fbfab635ba7226e4
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Citations in the corpus
- The Microbiome and the Respiratory Tract (2015, background): “The intestinal microbiota of young children are highly dynamic before stabilizing at approximately 3 years of age to resemble those of adults (67), a pattern of community maturation that is recapitulated in the microbiota of the upper respiratory tract (68, 69).”
- The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation (2016, background): “Asthma, allergies and autoimmune diabetes have all been linked to antibiotic use [6, 10, 61]”