Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

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Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. (2002, background): “Polyclonal antisera against full-length et al., 2001a), although the biological roles of only a few (FL antibody) or amino acids 448–802 of SU(Z)12 (SAC of these are known (e.g., Nakayama et al., 2001). antibody) were generated and affinity-purified.”
Insulators: many functions, many mechanisms. (2002, background): “Recent findings support a stepwise model in which the heterochromatin-associated protein HP1 specifically interacts with histone H3 only when Lys 9 has become methylated (Bannister et al. 2001; Lachner et al. 2001; Nakayama et al. 2001).”
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. (2002, background): “Recombinant histone H3(50 mM Tris-HCl [pH 7.8], 10% glycerol, 0.5 mM dithiothreitol, 1 mM bearing mutations K9A, K27A, or both was expressed in bacteriaPMSF [Nakayama et al., 2001]), 1.25 Ci 3H-S-Adenosyl methionine from plasmids kindly provided by D. Reinberg.”
RNAi-mediated chromatin silencing in fission yeast. (2008, background): “Clr4 has been shown to be required for the association of Swi6 with outer repeat heterochromatin at centromeres, the mating-type locus and telomeres (Ekwall et al. 1996; Nakayama et al. 2001; Partridge et al. 2000).”