A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene

By K. Salehi-Ashtiani, A. Lupták, A. Litovchick, J. Szostak. 2006

296 citations recorded by the source corpus.

Subfields: Hepatology, Immunology, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hepatology

1. Yong‐Zhen Zhang
2. Edward C. Holmes

In Molecular Biology

1. Yong‐Zhen Zhang
2. Edward C. Holmes
3. David S. Wishart
4. Jeremy K. Nicholson

Citations in the corpus

• Unprecedented genomic diversity of RNA viruses in arthropods reveals the ancestry of negative-sense RNA viruses (2015, background): “To date, the only known circular RNA virus is (hepatitis) deltavirus, although this potentially originated from the human genome (Salehi-Ashtiani et al., 2006) and requires hepatitis B virus for successful replication.”
• Anticodon-like loop-mediated dimerization in the crystal structures of HDV-like CPEB3 ribozymes (2023, methodology): “In 2006, using a human transcriptomic library designed for searching ribozymes, the Szostak group discovered a new self-cleaving ribozyme located in the second intron in the pre-mRNA encoding the cytoplasmic polyadenylation element binding 3 protein (CPEB3) (9) (Figure 1B).”
• The Evolution and Emergence of RNA Viruses (2009, background): “A dramatic proof of this principle was the observation that the HDV ribozyme is related to the CPEB3 ribozyme present in a human intron sequence (Salehi-Ashtiani et al. 2006).”