Unprecedented genomic diversity of RNA viruses in arthropods reveals the ancestry of negative-sense RNA viruses
By Ci-xiu Li, M. Shi, Jun-hua Tian, Xian-dan Lin, Yan-jun Kang, Liang-Jun Chen, X. Qin, Jianguo Xu, Edward C. Holmes, Yong‐Zhen Zhang. eLife, 2015
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Although arthropods are important viral vectors, the biodiversity of arthropod viruses, as well as the role that arthropods have played in viral origins and evolution, is unclear. Through RNA sequencing of 70 arthropod species we discovered 112 novel viruses that appear to be ancestral to much of the documented genetic diversity of negative-sense RNA viruses, a number of which are also present as endogenous genomic copies. With this greatly enriched diversity we revealed that arthropods contain viruses that fall basal to major virus groups, including the vertebrate-specific arenaviruses, filoviruses, hantaviruses, influenza viruses, lyssaviruses, and paramyxoviruses. We similarly documented a remarkable diversity of genome structures in arthropod viruses, including a putative circular form, that sheds new light on the evolution of genome organization. Hence, arthropods are a major reservoir of viral genetic diversity and have likely been central to viral evolution. DOI: http://dx.doi.org/10.7554/eLife.05378.001
Subfields: Infectious Diseases, Insect Science, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/46df99422d73a3fde815615f1b192fe44f014b14
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Citations in the corpus
- VirSorter2: a multi-classifier, expert-guided approach to detect diverse DNA and RNA viruses (2021, neutral): “…viruses of bacteria and archaea, vast stores of previously unidentified viruses that infect eukaryotes including ssDNA viruses [22], RNA viruses [23 – 25], and giant viruses (the phylum Nucleocytoviricota , also known as NucleoCytoplasmic Large DNA Viruses [NCLDV]) [19, 26] are being…”
- TAXONOMY OF THE ORDER MONONEGAVIRALES: UPDATE 2016 (2016, background): “These viruses include Sclerotinia sclerotiorum negative-stranded RNA virus 1 (SsNSRV-1) found in an ascomycete in China [16]; Sunshine Coast virus (SunCV; previously called Sunshine virus) isolated from Australian carpet pythons [10]; and Lı́shı́ spider virus 2 (LsSV-2), Sānxiá water strider virus 4”