Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?

By Richard J. Johnson, D. Kang, D. Feig, S. Kivlighn, J. Kanellis, Susumu Watanabe, Katherine R. Tuttle, B. Rodriguez-Iturbe, J. Herrera-Acosta, M. Mazzali. HYPERTENSION, 2003

1,368 citations recorded by the source corpus.

Subfields: Nephrology, Pathology and Forensic Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/76916544cbbd4d2cc04e24b1e95e9d907d3a00af

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In Nephrology

1. Y. Sautin
2. Richard J. Johnson

Citations in the corpus

• Uric acid and inflammatory markers. (2006, background): “These findings suggest that UA is not only a marker of catabolic rate but also might be actively involved in systemic inflammation, which is an important component of the causal pathway leading to hypertension, vascular diseases, and renal failure.(10) Given the epidemiological nature of our observa”
• Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. (2007, background): “On the other hand, hyperuricemia even without crystal deposition and gout is strongly associated with cardiovascular disease, kidney disease, and hypertension, increasing the risk of mortality (21).”
• Uric Acid: The Oxidant-Antioxidant Paradox (2008, background): “On the other hand, a vast literature on the epidemiology of cardiovascular disease, hypertension, and metabolic syndrome overwhelmingly shows that, at least among modern Homo sapiens, a high level of uric acid is strongly associated and in many cases predicts development of hypertension,[5−7] viscer”