Protein misfolding in the endoplasmic reticulum as a conduit to human disease

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Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease. (2018, neutral): “factor, termed spliced XBP1 (XBP1s)(6).”
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets (2023, background): “10,11 Unfolded protein response pathway PERK-eIF2 α -”
The Unfolded Protein Response and Cell Fate Control. (2017, neutral): “…of a complex network of interconnected signaling pathways initiated by the stimulation of three signal transducers located in the ER known as IRE1 (a and b), activating transcription factor6—ATF6—(a and b) and protein kinase RNA (PKR)-like ER kinase (PERK) (Figure 1) (Wang and Kaufman, 2016).”
The integrated stress response (2016, neutral): “Two models for the activation of PERK by ER stress have been put forward [26,27].”
Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine. (2019, background): “The endoplasmic reticulum is an important cellular organelle for the proper folding and transport of proteins [221].”