Temozolomide: mechanisms of action, repair and resistance.

By Jihong Zhang, M. Stevens, T. Bradshaw. Current Molecular Pharmacology, 2012

819 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/7682dbbb492e528db21ab6f613ce52f11249e07f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. D. de Bono
2. Mark J. O'Connor
3. Yves Pommier

In Oncology

1. J. D. de Bono
2. Mark J. O'Connor
3. Yves Pommier

Citations in the corpus

• Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action (2016, background): “Temozolomide acts by methylating guanines at positions O6 and N7 and adenines at position N3 (61).”
• Glioma Subclassifications and Their Clinical Significance (2017, background): “O6-Methylguanine induction is believed to be the primary cytotoxic event, leading to the insertion of thymine instead of cytosine during cellular replication, causing double-strand breaks, failure of DNA replication, and ultimately cell death [7].”