Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial.

By J. Durga, M. V. van Boxtel, E. Schouten, F. Kok, J. Jolles, M. Katan, P. Verhoef. The Lancet, 2007

726 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review (2016, background): “Examples of the latter include positive findings in groups suffering high levels of homocysteine at the outset [132,133].”
Brain foods: the effects of nutrients on brain function (2008, neutral): “The results of a recent randomized clinical trial indicated that a 3-year folic acid supplementation can help to reduce the age-related decline in cognitive functio”
Is folic acid good for everyone? (2008, background): “8 mg/d) for 3 y showed improved performance on certain cognitive tests compared with those who took placebo (63).”
Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial (2010, positive): “. Second, when we looked for significant predictors of the final cognitive test score, the rate of atrophy was one of the three main factors determining the final MMSE and TICS-M scores. Third, two other randomised controlled trials of homocysteine-lowering treatments have shown effects on cognition”