Computational modeling of the EGF-receptor system: a paradigm for systems biology.

By H. Steven Wiley, Stanislav Y. Shvartsman, Douglas A. Lauffenburger. Trends in Cell Biology, 2003

369 citations recorded by the source corpus.

Subfields: Biophysics, Modeling and Simulation, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/76358e66fa1ccdcd83567315f0655eb511423d28

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biophysics

1. J. Sáez-Rodríguez
2. Matthias Mann
3. Boris N. Kholodenko
4. Paul C. Bressloff
5. Jay M. Newby
6. Y. Yarden
7. Stephen Coombes

In Modeling and Simulation

1. Boris N. Kholodenko
2. Paul C. Bressloff
3. Jay M. Newby
4. Y. Yarden

In Molecular Biology

1. Matthias Mann
2. Shao-En Ong
3. Ernst Dieter Gilles
4. J. Sáez-Rodríguez
5. Y. Yarden
6. Steffen Klamt
7. Jonathan A. Lindquist
8. Luca Simeoni

Citations in the corpus

• Stochastic models of intracellular transport (2013, background): “For a detailed discussion of whole cell kinetic models of receptor recycling and its role in chemical signaling see Lauffenburger (1996); Wiley et al. (2003).”
• A Logical Model Provides Insights into T Cell Receptor Signaling (2007, background): “Dynamic models provide an optimal basis for a detailed study of cellular networks and have been applied successfully to cellular networks of moderate size [2–5].”
• Cell-signalling dynamics in time and space (2006, background): “EGFR is not only the best-studied RTK, but together with other members of the ErbB family it has a pivotal role in carcinogenesi”
• Structural and functional analysis of cellular networks with CellNetAnalyzer (2007, neutral): “The arguably most common formalism for cellular networks is kinetic modelling, which has been successfully applied to the study of single pathways and networks of moderate size (e.g. [1,2]).”
• Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. (2007, background): “We have identified a mechanism for metabolic regulation of cellular transition between growth and arrest in mammals arising from apparent coevolution of N-glycan number and branching.”
• Derailed endocytosis: an emerging feature of cancer (2008, background): “Brisk sequestration of the activated receptor into invaginating pits, and its endosomal sorting for degradation, precludes prolonged firin”
• Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics (2004, background): “EGFR has been a case study for the modeling of signaling for several decade”