A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

By P. Nolan, J. Peters, M. Strivens, D. Rogers, J. Hagan, N. Spurr, I. Gray, L. Vizor, D. Brooker, E. Whitehill and 34 more. Nature Genetics, 2000

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In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice (2004, background): “This will enable researchers to demonstrate altered behavior without any assumptions of the nature of the mutated genes”
Tests to assess motor phenotype in mice: a user's guide (2009, neutral): “This has been driven in part by the need for standardized phenotype screening in large-scale programmes of genetic variation, such as the Harwell mouse mutagenesis programm”
Loss-of-function approaches in comparative physiology: is there a future for knockdown experiments in the era of genome editing? (2019, background): “While mutant lines (see Glossary) in many species were initially established through forward genetic screens (Brenner, 1974; Nüsslein-volhard and Wieschaus, 1980; Haffter et al., 1996; Driever et al., 1996; Nolan et al., 2000; de Angelis et al., 2000), the recent development of zinc-finger nucleases”