Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55Gag

By Lynn Verplank, F. Bouamr, Tracy J. LaGrassa, B. Agresta, Alexandra Kikonyogo, J. Leis, C. Carter. Proceedings of the National Academy of Sciences of the United States of America, 2001

627 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Virology

View Paper: https://www.semanticscholar.org/paper/75e56e966af1369eb51fd9546ff32f638186b195

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1. Wesley I. Sundquist

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Citations in the corpus

• HIV-1 assembly, budding, and maturation. (2012, background): “The primary “PTAP” late domain binds the TSG101 subunit of the heterotetrameric ESCRT-I complex (Garrus et al. 2001; Martin-Serrano et al. 2001; VerPlank et al. 2001; Demirov et al. 2002; Morita and Sundquist 2004; Bieniasz 2009).”
• Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein (2012, background): “In the late domain of HIV Gag is a critical PTAP motif that interacts with the UEV domain of TSG101 (19, 20), enabling Gag to recruit TSG101 and other ESCRT proteins, which normally reside on endosomal membranes, to the cell surface (12, 21, 22).”
• The protein network of HIV budding. (2003, background): “CHMP5 constructs were toxic or self-activating, VerPlank et al., 2001), [6] (Bishop and Woodman, 2001), [7] (Kamura et al., 2001), [8] and [9] (Howard et al., 2001), [10] (Scheuring et al., 2001), [12] (Chatellard-Causse et al., 2002) and [14] (Strack et al., 2003).”
• Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. (2001, background): “UEV proteins are homologous to the E2 class of ubiquitin conjugating enzymes, but lack the active siteing protein (VerPlank et al., 2001).”
• PPPYEPTAP Motif Is the Late Domain of Human T-Cell Leukemia Virus Type 1 Gag and Mediates Its Functional Interaction with Cellular Proteins Nedd4 and Tsg101 (2003, methodology): “The positive controls confirmed the activities of the constructs: the HIV-1 Gag bound Tsg101 as previously described (13, 35, 61 ) but not with Nedd4, and MLV Gag interacted with Nedd4 protein but not with Tsg101.”