Repair of endogenous DNA damage.

By Tomas Lindahl, D. Barnes. Cold Spring Harbor Symposia on Quantitative Biology, 2000

692 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/75dc16efa5f679940965178530b5b3c495186f14

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Stephen P. Jackson
2. J. Bartek
3. Stephen J. Elledge
4. Pingkun Zhou
5. Alberto Ciccia
6. D. Hanahan
7. R. Weinberg
8. Yves Pommier

In Genetics

1. Stephen P. Jackson
2. Isaac S. Kohane
3. Joshua Charles Denny
4. Wei-Qi Wei
5. D. G. Gibson

In Molecular Biology

1. Stephen P. Jackson
2. J. Bartek
3. Stephen J. Elledge
4. Pingkun Zhou
5. Alberto Ciccia
6. Ruixue Huang
7. Tomas Lindahl
8. Isaac S. Kohane

Citations in the corpus

• The DNA Damage Response: Making it safe to play with knives (2010, background): “Mispaired DNA bases are replaced with correct bases by mismatch repair (MMR), and small chemical alterations of DNA bases are repaired by base excision repair (BER) through excision of the damaged base (Jiricny, 2006; Lindahl and Barnes, 2000).”
• Repair and genetic consequences of endogenous DNA base damage in mammalian cells. (2004, background): “The total load of AP sites in a mammalian cell from these sources is over 10,000 per day and is a challenge to the cellular base excision-repair system (85).”
• DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy (2021, background): “reported that, each day, our cells may be subject to around 70,000 instances of DNA damage.(100) Most of these lesions are single-strand breaks, and only a few are DSBs, which are less frequent.”
• Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. (2006, neutral): “…(SSBs) that arise spontaneously, such as those from endogenous alkylation, oxidation, and deamination events, as well as small, nonhelix-distorting DNA lesions induced by chemical mutagens such as the alkylating agent methyl-methane sulphonate (MMS; (Lindahl and Barnes, 2000; Sancar et al., 2004).”
• Gene regulation and DNA damage in the ageing human brain (2004, methodology): “To obtain greater insight into the effects of DNA damage on gene expression, we produced human neuroblastoma SH-SY5Y cell lines that stably overexpress the base-excision repair enzyme human OGG”
• The DNA-damage response in human biology and disease (2009, background): “ach of the , 10 13 cells in the human body receives tens of thousands of DNA lesions per day 1 .”