Epigenetic mechanisms regulating longevity and aging

By Payel Sen, P. Shah, Raffaella Nativio, S. Berger. Cell, 2016

805 citations recorded by the source corpus.

Summary Aging is an inevitable outcome of life, characterized by progressive decline in tissue and organ function and increased risk of mortality. Accumulating evidence links aging to genetic and epigenetic alterations. Given the reversible nature of epigenetic mechanisms, these pathways provide promising avenues for therapeutics against age-related decline and disease. In this review, we provide a comprehensive overview of epigenetic studies from invertebrate organisms, vertebrate models, tissue and in vitro systems. We establish links between common operative aging pathways and hallmark chromatin signatures that can be used to identify “druggable” targets to counter human aging and age-related disease.

Subfields: Aging, Pediatrics, Perinatology and Child Health, Physiology

View Paper: https://www.semanticscholar.org/paper/757dfff4f7cb7b9994aaf7a4de96e197455ebad1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Nir Barzilai

In Physiology

1. T. von Zglinicki
2. G. Núñez
3. Nir Barzilai

Citations in the corpus

• Immunosenescence: molecular mechanisms and diseases (2023, background): “However, the underlying mechanisms responsible for these alterations are not yet known.(81)”
• In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming (2016, positive): “Epigenetic alterations (e.g., DNA methylation, post-translational modifications of histones, and chromatin remodeling) have recently emerged as one of the most conserved hallmarks of aging (Benayoun et al., 2015; Sen et al., 2016).”
• Mitochondrial dysfunction in cell senescence and aging (2022, background): “These include deregulated nutrient signaling (14, 15), autophagy/mitophagy dysfunction (16), and massive epigenetic reprogramming (17, 18), including activation of (proinflammatory) transcription factors driving the senescence-associated secretory phenotype (SASP) (19–22).”
• Epigenetic plasticity and the hallmarks of cancer (2017, background): “Studies withmodel organisms have documented changes in global histone methylation patterns and established causal roles for the corresponding modifying enzymes in longevity (80, 81).”
• Benefits of Metformin in Attenuating the Hallmarks of Aging (2020, background): “Epigenetic alterations—Loss of histones, imbalance in histone modifications, changes in chromatin architecture, breakdown of the nuclear lamina, as well as DNA and histone methylation changes are characteristics of biological aging (Sen et al. 2016).”
• Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “Additionally, it is associated with the development of many chronic diseases, including cardiovascular disease and neurodegenerative disorders.47 Aseptic inflammation is an important marker of immune senescence and has been reported to be triggered by endogenous cellular DNA.47,48 A recent study ide”