The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis
By D. Mosser, A. Caron, L. Bourget, A. Meriin, M. Sherman, Richard I. Morimoto, B. Massie. Molecular and Cellular Biology, 2000
762 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/757c5b36d1aedeea0dd19063b9f512ed83ba7e27
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In Cell Biology
In Molecular Biology
- L. Whitesell
- Susan Lindquist
- H. Beere
- N. Holbrook
- J. Martindale
- M. Jäättelä
- Richard I. Morimoto
- R. Kaufman
Citations in the corpus
- Cellular response to oxidative stress: Signaling for suicide and survival * (2002, background): “For example, Hsp72 has been shown to both inhibit cytochrome C release and suppress processing and activity of caspases (Mosser et al., 1997, 2000; Buzzard et al., 1998; Creagh et al., 2000b).”
- HSP90 and the chaperoning of cancer (2005, background): “Inhibition of stress-induced apoptosis by HSP70 seems to require its intact chaperone activit”
- The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions (2007, background): “protective effect, and Hsp70-1 has been suggested to inhibit the accumulation of protein aggregates and thereby to remove the stimulus that triggers cell death [58,59].”
- `The stress of dying': the role of heat shock proteins in the regulation of apoptosis (2004, background): “2645Hsps and apoptosis regulation cytochrome c release (Mosser et al., 2000), both mechanisms might function in a complementary manner to ensure an effective, ‘multi-hit’ Hsp-mediated suppression of apoptosis.”
- Medical application of functionalized magnetic nanoparticles. (2005, background): “tosis (53), HSP expression is considered to be a complicating factor in hyperthermia.”
- Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action (2006, background): “Hsp70 is an antiapoptotic chaperone protein (251) that inhibits mitochondrial release of cytochrome c and blocks procaspase 9 recruitment to the apoptosome complex (16).”
- Heat Shock-Induced Apoptosis in Preimplantation Bovine Embryos Is a Developmentally Regulated Phenomenon (2002, background): “HSP70 also blocks cytochrome c release from mitochondria [ 44 ], processing of inactive procaspase-3 [30], and SAPK/ JNK activation [30].”