Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

By M. Hsu, Jie Zhang, M. Flint, C. Logvinoff, C. Cheng‐Mayer, Charles M. Rice, J. McKeating. Proceedings of the National Academy of Sciences of the United States of America, 2003

887 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/750675184e012853efc691a0c74c4036e2a99e1a

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Citations in the corpus

Immunobiology and pathogenesis of viral hepatitis. (2006, background): “Furthermore, antibodies specific for HCV E1 and E2 glycoproteins can block the infection of susceptible cells with pseudotyped lentiviral vectors expressing these envelope proteins (45, 50, 51).”
Flaviviridae :T he Viruses and Their Replication (2007, background): “Productive entry depends on acidification of the endosomal compartment, most likely to trigger rearrangement of the HCV glycoproteins into their fusogenic form (284,721).”
Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis (2006, methodology): “The importance of CD81 and SR-BI in HCV entry was confirmed with HCVpp (3, 4, 24) as well as with HCVcc for CD81 (30, 56).”
Replication of hepatitis C virus (2007, background): “, pseudoparticles (engineered retroviral particles bearing functional HCV envelope proteins) that enable the study of viral entry under reproducible and conveniently measurable condition”
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome (2005, positive): “Neutralization of HCV infection by CD81-specific antibody CD81 was shown to be involved in HCV entry using HCV pseudoparticle”