Mesenchymal Stromal Cells: Current Understanding and Clinical Status
By H. Salem, C. Thiemermann. Stem Cells, 2009
951 citations recorded by the source corpus.
Multipotent mesenchymal stromal cells (MSCs) represent a rare heterogeneous subset of pluripotent stromal cells that can be isolated from many different adult tissues that exhibit the potential to give rise to cells of diverse lineages. Numerous studies have reported beneficial effects of MSCs in tissue repair and regeneration. After culture expansion and in vivo administration, MSCs home to and engraft to injured tissues and modulate the inflammatory response through synergistic downregulation of proinflammatory cytokines and upregulation of both prosurvival and antiinflammatory factors. In addition, MSCs possess remarkable immunosuppressive properties, suppressing T‐cell, NK cell functions, and also modulating dentritic cell activities. Tremendous progress has been made in preclinical studies using MSCs, including the ability to use allogeneic cells, which has driven the application of MSCs toward the clinical setting. This review highlights our current understanding into the biology of MSCs with particular emphasis on the cardiovascular and renal applications, and provides a brief update on the clinical status of MSC‐based therapy. STEM CELLS 2010;28:585–596
Subfields: Genetics, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/749b4ba65ebdf786d8fcc6c38cab3454cb283ba5
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Citations in the corpus
- Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. (2013, background): “MSCs are also known to have immunosuppressive properties and therefore could be used in allogenic transplantation [75,79,80,84].”
- Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion (2012, background): “Mesenchymal stem cells (MSC) are considered as a potential therapy for a wide variety of degenerating and immunological disorders (Giordano et al., 2007; Reinders et al., 2010; Salem and Thiemermann, 2010).”