Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
By Patrick Westfall, D. Pitera, Jacob Lenihan, Diana Eng, F. Woolard, R. Regentin, Tizita Horning, H. Tsuruta, D. Melis, Andrew E. Owens and 9 more. Proceedings of the National Academy of Sciences of the United States of America, 2012
676 citations recorded by the source corpus.
Subfields: Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/741eafcabdb87c3855054a4288ac080cd6cff755
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Citations in the corpus
- High-level semi-synthetic production of the potent antimalarial artemisinin (2013, background): “(PGAL3) (nucleotides 21 to 2660) integrated between GAL1 and GAL7 (gal1/ 10/7D::natA_PGAL3-CPR1-TCYC1, in which TCYC1 denotes the CYC1 terminator); (3) a single integrated copy of A.”
- Engineering Cellular Metabolism (2008, neutral): “…heterologous expression requires enzyme discovery as part of 1186 Cell 164, March 10, 2016 ª2016 Elsevier Inc. the metabolic engineering program, as illustrated for production of artemisinic acid (Ro et al., 2006; Westfall et al., 2012; Paddon et al., 2013) and opioids (Galanie et al., 2015).”