TREM-1 amplifies inflammation and is a crucial mediator of septic shock

By A. Bouchon, F. Facchetti, M. Weigand, M. Colonna. Nature, 2001

1,065 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/738a3fce6eaa0b7c0427701771d35f15128bab67

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mócsai
2. N. Borregaard
3. C. Lowell
4. T. Mayadas
5. X. Cullere
6. K. Futosi
7. Szabina Fodor
8. M. Colonna

Citations in the corpus

• Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. (2002, background): “TREM1 is strongly up-regulated in cells that mediate acute inflammatory responses to bacterial infection (i.e., neutrophils and monocytes) (Bouchon et al. 2001a), whereas TREM2 is expressed on macrophages and monocyte-derived dendritic cells, suggesting that TREM2 plays a role in chronic, rather…”
• The TREM receptor family and signal integration (2006, background): “TREM-1: inflammatory amplifier TREM 1 is expressed on neutrophils and monocytes and serves as a critical amplifier of inflammatory signalin”
• Neutrophils, from marrow to microbes. (2010, background): “…of the triggering receptor expressed on myeloid cells (TREM-1) (by ligands not yet identified; Ford and McVicar, 2009), which is upregulated (Bouchon et al., 2000, 2001) and signals through DAP12 (presented earlier) (Bouchon et al., 2000; Tessarz and Cerwenka, 2008), may lead to…”
• TREMs in the immune system and beyond (2003, background): “Furthermore, TREM1 is expressed at high levels by neutrophilic infiltrates and epithelial cells in human skin and lymph nodes that are infected by Gram-positive and -negative bacteria, as well as fung”
• Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “Those include DAP12and FcRγ-associated receptors such as TREM-1 [226,227] and OSCAR [228]; the Neisseria recognition receptor CEACAM3 [229,230]; as well as scavenger receptors, complement receptors and various intracellular lipid-sensing receptors.”
• The Multifaceted Functions of Neutrophils (2013, background): “Antibody-mediated blockade of TREM-1 protects against endotoxic shock in mice (73).”