Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

By Ingunn M. Stromnes, Lauren Cerretti, D. Liggitt, R. Harris, J. Goverman. Nature Medicine, 2008

668 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “These characteristics can also affect the cytokine production bias during T helper differentiation (40, 41).”
Fate mapping of interleukin 17-producing T cells in inflammatory responses (2011, background): “The relative roles of IL-17A and IFN-γ in the pathology of EAE, as well as in multiple sclerosis in humans, remain controversial, with evidence supporting the proposal of both protective as well as pathogenic involvement of IFN-γ in central nervous system inflammatio”
C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE (2009, background): “and the T H -17/T H 1 ratio of infiltrating cells determines where inflammation occurs in the CN”
Functional morphology of the blood-brain barrier in health and disease (2018, neutral): “These cells are distinguished by secretion of unique effector cytokines that have distinct effects in either promoting axonal damage and oligodendrocyte death or inducing BBB dysfunction [123].”