A Genomic Perspective on the Origin and Emergence of SARS-CoV-2

By Yong‐Zhen Zhang, Edward C. Holmes. Cell, 2020

710 citations recorded by the source corpus.

The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins.

Subfields: Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/73377d67a141c1671df4337022e64f8c27dbf702

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In Infectious Diseases

1. A. Aschenbrenner
2. Philippe Lemey
3. Joachim L. Schultze
4. Maciej F. Boni
5. Andrew Rambaut

Citations in the corpus

• Mechanisms of SARS-CoV-2 Transmission and Pathogenesis (2020, neutral): “Its genome comprises 14 open reading frames (ORFs), two-thirds of which encode 16 nonstructural proteins (nsp 1–16) that make up the replicase complex [6,7].”
• Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic (2020, positive): “…have acted as an intermediate species facilitating transmission to humans, the evidence is consistent with the virus having evolved in bats resulting in bat sarbecoviruses that can replicate in the upper respiratory tract of both humans and pangolins (Zhang and Holmes, 2020; Zhou et al., 2020a).”
• COVID-19 and the human innate immune system (2021, background): “…they identified 13, mainly loss-of-function mutations, associated with severe COVID-19 disease course in the TLR3, IRF7, and IRF9 pathways (Zhang et al., 2020a) (Figure 5). pDCs from IRF7-deficient patients produced no type I IFN when infected with SARS-CoV-2, and fibroblasts from…”
• Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach (2020, positive): “Comparative sequence analysis of the SARS-CoV-2 genome indicates striking similarities to the BAT-CoV, suggesting a possible mammalian origin from bats in the Wuhan city of China [31].”