Cholesterol sensing, trafficking, and esterification.

By Ta-Yuan Chang, C. Chang, N. Ohgami, Y. Yamauchi. Annual Review of Cell and Developmental Biology, 2006

603 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/732b3d8d7dfba485ec950c2b6e9bfeb3e344bdf8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. P. Tontonoz

In Molecular Biology

1. P. Tontonoz
2. S. Bensinger
3. N. Zelcer
4. H. Chae
5. Judith Klumperman
6. P. Saftig
7. Hyung-Ryong Kim
8. Tae‐Wan Kim

In Surgery

1. P. Tontonoz
2. S. Bensinger
3. N. Zelcer
4. P. Edwards
5. I. Tabas
6. K. Bornfeldt

Citations in the corpus

• Endoplasmic Reticulum Stress and Associated ROS (2016, background): “The ER is the primary organelle for secretory pathways in all eukaryotic cells [1,2].”
• Metabolic Response to Monthly Variations of Sparus aurata Reared in (2014, neutral): “Cholesterol is one of the components of cell membranes and an important raw material for synthesis of steroid hormones, while triglycerides can store energy (Chang et al., 2006).”
• Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function (2009, background): “Other examples of ion and protein transport over the lysosomal limiting membrane through channels or by transporters include chloride transport through chloride channel protein 7 ( ClC7 ), cystine transport through cystinosin, sialic acid transport through sialin , cobalamin transfer by the cobalam”
• The Cellular Biology of Macrophages in Atherosclerosis (2011, neutral): “The mechanisms and exact route of cholesterol transport to the plasma membrane are not fully known, although Golgi-to-plasma membrane vesicular transport may be involved (Chang et al., 2006; Maxfield and Tabas, 2005).”
• LXR signaling couples sterol metabolism to proliferation in the acquired immune response (2008, background): “However, intracellular cholesterol trafficking is complex, and intracellular pools are not necessarily in equilibrium with the plasma membrane (Chang et al., 2006; Simons and Ikonen, 2000).”
• Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness (2014, background): “Because cholesterol esterification is known to play a vital role in maintaining intracellular cholesterol homeostasis (Chang et al., 2006), we hypothesized that abrogating ACAT activity can inhibit PCa growth by elevating free cholesterol levels, downregulating expression levels of SREBP and LDLr, a”
• Linking Lipids to Alzheimer’s Disease: Cholesterol and Beyond (2011, background): “html">Supplementary information S1 (box)), followed by accumulation in intracellular lipid droplets or efflux through the plasma membrane into the extracellular environmen”