Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

By C. Niswender, P. Conn. Annual Review of Pharmacology and Toxicology, 2010

1,826 citations recorded by the source corpus.

The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors that participate in the modulation of synaptic transmission and neuronal excitability throughout the central nervous system. The mGluRs bind glutamate within a large extracellular domain and transmit signals through the receptor protein to intracellular signaling partners. A great deal of progress has been made in determining the mechanisms by which mGluRs are activated, proteins with which they interact, and orthosteric and allosteric ligands that can modulate receptor activity. The widespread expression of mGluRs makes these receptors particularly attractive drug targets, and recent studies continue to validate the therapeutic utility of mGluR ligands in neurological and psychiatric disorders such as Alzheimer’s disease, Parkinson’s disease, anxiety, depression, and schizophrenia.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/72ff4189dd1d1b3928cc1864bcbe0a55a04743ee

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Yun Zhou
2. C. Varela
3. D. Schoepp
4. N. Danbolt
5. G. Collingridge
6. M. Millan

In Molecular Biology

1. C. Varela
2. P. Conn
3. Yun Zhou
4. D. Schoepp
5. N. Danbolt
6. G. Collingridge

Citations in the corpus

• Thalamic neuromodulation and its implications for executive networks (2014, background): “Although with exceptions, group I mGluRs are postsynaptic, and groups II and III are localized in presynaptic terminals (Niswender and Conn, 2010).”
• Neuronal activity-dependent control of postnatal neurogenesis and gliogenesis (2018, neutral): “…& Panzanelli 2014, Greger et al. 2017, Iacobucci & Popescu 2017, Yakel 2014) and (b) metabotropic G protein–coupled receptors (GPCRs) with slower kinetics [muscarinic receptor, GABAB, and metabotropic glutamate receptors (mGluRs)] (Kruse et al. 2014, Niswender & Conn 2010, Pin & Bettler 2016).”
• Glutamate as a neurotransmitter in the healthy brain (2014, background): “…glutamate transporter) GABA c-Aminobutyric acid GLAST Glutamate transporter number 1 (EAAT1; slc1a3; Storck et al. 1992; Tanaka 1993a) GLT-1 Glutamate transporter number 2 (EAAT2; slc1a2; Pines et al. 1992) GLUL Glutamine synthetase NMDA N-Methyl-D-aspartate TBOA DL-threo-b-benzyloxyaspartate”
• Metabotropic glutamate receptors: From the workbench to the bedside (2010, background): “Synaptic glutamate can therefore activate all three receptor subtypes, thus negatively regulating its own release (reviewed by Niswender and Conn, 2010).”
• Physiology of Astroglia. (2018, neutral): “In general, group I receptors are coupled to PLC/InsP3/Ca 2 release cascade, whereas receptors from groups II and III are coupled to adenylyl cyclase (1231).”
• Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density (2016, background): “Located primarily on post-synaptic structures, they couple predominately to Gq G-proteins to activate a number of downstream signaling pathways that have both acute and long-term effects on neuronal excitability [1].”