Transcription-coupled DNA repair: two decades of progress and surprises

By P. Hanawalt, G. Spivak. Nature reviews. Molecular cell biology, 2008

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How researchers see this paper

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DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy (2021, background): “The DNA damage in the active transcription gene or the transcribing strand is preferentially repair through the transcription-coupled repair sub-pathway.(188,190) Global genome repair is another sub-pathway of nucleotide excision repair, through which the DNA damage in whole genome is repaired with ”
The DNA Damage Response: Making it safe to play with knives (2010, background): “Bulky DNA lesions, such as UV-induced pyrimidine dimers, in transcribed genes can lead to RNA polymerase II stalling (Hanawalt and Spivak, 2008).”
Signatures of mutational processes in human cancer (2013, positive): “Beyond these known examples of DNA damage processed by transcription-coupled NER, other signatures show strong transcriptional strand bias (5, 8, 10, 12, 16).”
Mutational Processes Molding the Genomes of 21 Breast Cancers (2012, background): “Both can cause damage to guanine and, although preferentially repaired by BER, some lesions can be substrates for TCR (Hanawalt and Spivak, 2008).”
Nucleotide excision repair in eukaryotes. (2013, background): “NER can be initiated by two subpathways: global genome NER (GG-NER) or transcription-coupled NER (TC-NER; Gillet and Schärer 2006; Hanawalt and Spivak 2008).”