Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change.

By You Han Bae, S. Fukushima, Atsushi Harada, Kazunori Kataoka. Angewandte Chemie, 2003

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Supramolecular assemblies of block copolymers in aqueous media as nanocontainers relevant to biological applications (2006, background): “[78] Bae Y, Fukushima S, Harada A, Kataoka K.”
Biocompatibility of engineered nanoparticles for drug delivery. (2013, background): “ity, only a small number of them havemoved to the clinical studies [163] such as the pH-responsive polymeric micelles [164–169].”
Recent progress in tumor pH targeting nanotechnology. (2008, background): “Nanodrug carriers attached with surface ligands or antibodies exploit these receptor-mediated uptake pathways that are recognized and internalized by the tumor cells [14-18].”
Progress of drug-loaded polymeric micelles into clinical studies. (2014, neutral): “Therefore, pH-sensitive Dox-loaded micelles were constructed by conjugating Dox to PEG-bpoly(α,β-aspartic acid) via a hydrazone bond [50].”