Nanoparticle‐induced platelet aggregation and vascular thrombosis

By A. Radomski, P. Jurasz, D. Alonso‐Escolano, M. Drews, M. Morandi, T. Malinski, M. Radomski. British Journal of Pharmacology, 2005

633 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/71c04a8448a7cfadee0954f1b0ccc6c104f66542

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In Materials Chemistry

1. Zhuang Liu
2. Hongjie Dai
3. Kostas Kostarelos
4. M. Prato
5. A. Bianco
6. Xiaoming Sun
7. Ken Donaldson
8. M. Radomski

Citations in the corpus

• Adverse cardiovascular effects of air pollution (2009, result): “These findings are consistent with previous in vitro investigations, which demonstrated that the addition of diesel exhaust particles to human blood resulted in platelet aggregation and enhanced glycoprotein IIb/IIIa receptor expression”
• Carbon nanotubes as nanomedicines: from toxicology to pharmacology. (2006, background): “Radomsky et al.[25] have shown that platelets were easily targeted and activated by carbon nanotubes with consequent in vivo acceleration of the rate and time for the development of carotid artery thrombosis.”
• A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. (2008, background): “In the presence of high concentrations of SWNTs, ferric chloride activates platelets, leading to the formation of blood clot”
• Protein-Nanoparticle Interactions (2013, background): “The electrocatalytic properties of these electrodes can be further improved by incorporating metal nanoparticles [35], furthering neuroscience research on nerve stimulation [36], acute pain [37], and implantable drug-delivery systems [38].”
• Nanoparticles: pharmacological and toxicological significance (2007, background): “We have previously found that mixed carbon nanoparticles and nanotubes, both MWCNT and SWCNT, are able to induce platelet aggregation in vitro and, in addition accelerate the rate of vascular thrombosis in rat carotid artery (Radomski et al., 2005).”
• Drug delivery and nanoparticles: Applications and hazards (2008, background): “Recent studies with carbon derived nanomaterials showed that platelet aggregation was induced by both single and multi-wall carbon nanotubes, but not by the C60-fullerenes that are used as building blocks for these CNT (Radomski et al 2005).”
• Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties (2018, background): “Experiments modeling the toxic effects of NPs on the body have shown that NPs cause thrombosis by enhancing platelet aggregation [35], inflammation of the upper and lower respiratory tracts, neurodegenerative disorders, stroke, myocardial infarction, and other disorders [36–38].”