A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

By L. Raamsdonk, Bas Teusink, D. Broadhurst, Nianshu Zhang, Andrew Hayes, Michael C. Walsh, J. Berden, Kevin M. Brindle, D. Kell, Jem J. Rowland and 3 more. Nature Biotechnology, 2001

1,019 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/71a191ea7138f1ead20122236c83caa986028b96

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Citations in the corpus

Statistical strategies for avoiding false discoveries in metabolomics and related experiments (2007, background): “…and Schuster, 1996; Cornish-Bowden and Ca´rdenas, 2000; Cascante et al., 2002), the variation in the metabolome is expected to be much greater (Raamsdonk et al., 2001; Urbanczyk-Wochniak et al., 2003; Kell, 2004), and thus we have the opportunity to achieve levels of statistical significance…”
Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism (2003, background): “From a modelling point of view, considerable advances have been made in correlating gene–protein–metabolite interactions in microorganisms in which linked processes in single cell types can be probed in dept”
Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement (2006, background): “Results Metabolite profiling So far, 'metabolomic' strategies have been concerned with obtaining quantitative information on the metabolome on a mutant or environmental basis with the widest possible coverag”
Genome-scale models of microbial cells: evaluating the consequences of constraints (2004, background): “The mathematical notion of equivalent optimal states is coincident with the biological notion of silent phenotypes 52–54 .”
The druggable genome (2002, background): “One route to target discovery might therefore lie in identifying enzymes and receptors from metabolomic profilin”
Metabolic profiles of cancer cells (2004, background): “Such approaches have found applications in phenotyping mutant and transgenic yeast, plants and mic”
Metabolomics – the link between genotypes and phenotypes (2004, methodology): “NMR was also used for metabolic fingerprints to detect differences between mutated yeast strains (Raamsdonk et al., 2001).”
Metabolomics by numbers: acquiring and understanding global metabolite data. (2004, background): “In particular, it is known from both the theory underlying metabolic control analysis [9,10] and experiment [ 11 ] that, although changes in the quantities of individual enzymes might be expected to have little effect on metabolic fluxes, they can and do have significant effects on the concentration”