Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism
By Jeremy K. Nicholson, Ian A. Wilson. Nature reviews. Drug discovery, 2003
1,065 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/497efcd13ec76f02d4344d2221b4da18770f4fd7
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- David S. Wishart
- Jeremy K. Nicholson
- Warwick B. Dunn
- Royston Goodacre
- David I. Ellis
- Markus R. Wenk
- Ian A. Wilson
- Edward C. Holmes
Citations in the corpus
- Application of Micro- and Nano-Electromechanical Devices to Drug Delivery (2006, background): “of fields that has the potential to greatly enrich discovery of therapeutic drugs and biomolecules (30,31).”
- Gut microorganisms, mammalian metabolism and personalized health care (2005, background): “We recently introduced a concept — global systems biology — to describe the investigation of the interactions of the mammalian transcriptomes, proteomes and METABOLOMES , the gut microbiota and other environmental factors on host metabolic regulatio”
- Impact of the gut microbiota on inflammation, obesity, and metabolic disease (2016, background): “The gut microbiota also produces pharmacologically active signaling molecules that interact with the metabolism of the host [8–10].”
- Metabolomics by numbers: acquiring and understanding global metabolite data. (2004, background): “NMR spectroscopy has been shown to provide valuable information on metabolites, typically directly from biofluids with little or no sample preparation steps [18, 19 ].”
- The challenges of modeling mammalian biocomplexity (2004, background): “The hope is that judicious use of genomic knowledge within a framework of physiology and metabolism will yield improvements in the health of whole populations and in the health of individuals by personalized healthcare solution”
- Mass spectrometry-based metabolomics. (2007, methodology): “The most trivial way to bring the mass-intensity vectors to uniform length is to bin them in a fashion similar to the approach widely used in NMR metabolomics (Holmes, Nicholson, & Tranter, 2001; Viant, 2003).”