Intracellular toll-like receptors.

By A. Blasius, B. Beutler. Immunity, 2010

1,255 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/3ead6653fc9fe75d371258b6c9b594c1362be622

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In Immunology

1. Shizuo Akira
2. Taro Kawai
3. R. Coffman
4. Yong‐jun Liu
5. A. Sher
6. R. Seder
7. Zhiqiang Zhang
8. R. Medzhitov

Citations in the corpus

• NF-κB in biology and targeted therapy: new insights and translational implications (2024, background): “68 The toll-IL-1 receptor (TIR) structural domain of TLR4 recruits the TLR adapter molecule MyD88 and the TIR domain containing adapter protein (TIRAP), which subsequently activate IRAK1/4 and TRAF6, and involved in TLR-stimulated NF-κ B signaling are also toll-like receptor adapter molecule 1…”
• The adapter MAVS promotes NLRP3 mitochondrial localization and inflammasome activation (2013, positive): “However, organellar recruitment is well recognized for plasma membrane-associated or endosomal TLRs (Blasius and Beutler, 2010) and for the RIGlike helicases (RIG-I and MDA-5) that engage the mitochondrial outer membrane protein MAVS (mitochondrial antiviral signaling protein) in pathways leading to”
• Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “…reoviruses) and dsRNA produced during replication of ssRNA viruses (such as influenza A virus [IAV], encephalomyocarditis virus [EMCV], and West Nile virus [WNV]) and dsDNA viruses (herpes simplex virus 1 [HSV-1] and murine cytomegarovirus [MCMV]) (Akira et al., 2006; Blasius and Beutler, 2010).”
• Activation of STING requires palmitoylation at the Golgi (2016, neutral): “Single mutations of Cys88 or Cys91 also reduced [ 3 H] labelling, but to a lesser extent (Supplementary Fig.”
• The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells (2011, background): “Thus far, it has been established that the Toll-like receptors (TLRs) TLR3, TLR7, TLR8 and TLR9 sense viral DNA or RNA in the endosom”
• Vaccine Adjuvants: Putting Innate Immunity to Work (2010, background): “Vaccines that lead to direct infection of cells, such as viral vectors or DNA, induce CD8+ T cell immunity through the endogenous class I presentation pathway; however, exogenous protein vaccines require cross-presentation.”
• Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “Upon CpG stimulation, a signaling cascade is elicited that leads to the production of proinflammatory cytokines and type I IFNs [23, 24], the latter being predominantly secreted by pDC.”