Chemokines in pathology and medicine

By M. Baggiolini. Journal of Internal Medicine, 2001

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Role of myokines in exercise and metabolism. (2007, background): “IL-8 belongs to a subdivision of CXC-chemokines, which has an amino acid sequence Glu-Leu-Arg (ELR) preceding the first conserved cysteine amino acid residue in the primary structure of these proteins (6).”
Muscle as an endocrine organ: focus on muscle-derived interleukin-6. (2008, background): “IL-8 belongs to a subdivision of CXCchemokines, which has an amino acid sequence Glu-LeuArg (ELR) preceding the first conserved cysteine amino acid residue in the primary structure of these proteins (14).”
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. (2014, background): “The CXC chemokines can be divided into two general subgroups (ELR and non-ELR) based upon the presence or absence of the amino acidmotif (Glu-Leu-Arg) immediately preceeding the first cysteine [65].”
Specific Recruitment of Antigen-presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory Fluids (2003, background): “They might indeed on one hand help to understand better the development of innate and adaptive immune responses, and on the other hand constitute tools or targets in therapeutic strategies aiming at modulating the immune responses in situations such as cancer, inflammatory diseases, and graft reject”