Novel genes identified in a high-density genome wide association study for nicotine dependence.
By L. Bierut, P. Madden, N. Breslau, Eric O. Johnson, D. Hatsukami, O. Pomerleau, G. Swan, J. Rutter, S. Bertelsen, Louis Fox and 12 more. Human Molecular Genetics, 2007
651 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/71780e9150d674049276b7c750abdf8dc066face
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Citations in the corpus
- Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics (2009, background): “Bierut, Saccone, and coworkers examined a phenotype that is thought to reflect a vulnerability to becoming dependent on nicotine (48, 49).”
- Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. (2007, methodology): “We therefore prioritized the category B genes using the results of the pooled genotyping from the companion GWAS study (23).”
- Variants in nicotinic receptors and risk for nicotine dependence. (2008, methodology): “Our group recently completed genome-wide association and candidate gene studies of nicotine dependence based on the contrast between nicotine-dependent smokers and smokers who used at least 100 cigarettes in their lifetime but never developed any symptoms of dependence (5, 6).”
- Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior (2010, background): “Among the genes at the two newly associated loci are genes encoding nicotine-metabolizing enzymes ( CYP2A6 and CYP2B6 ) and nicotinic acetylcholine receptor subunits ( CHRNB3 and CHRNA6 ), all of which have been highlighted in previous studies of smoking and nicotine dependenc”