Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring.

By K. Lillycrop, E. Phillips, A. Jackson, Mark A. Hanson, G. Burdge. Journal of NutriLife, 2005

1,137 citations recorded by the source corpus.

Subfields: Molecular Biology, Obstetrics and Gynecology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/70fca5804526521d4f94e714b10bfbe1b70e3d3f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Obstetrics and Gynecology

In Pediatrics, Perinatology and Child Health

Citations in the corpus

Child health, developmental plasticity, and epigenetic programming. (2011, background): “The results of these experiments showed that modest changes to maternal intake of macronutrients during pregnancy induce stable changes to the epigenetic regulation of GR and PPAR in the livers of the juvenile (459, 461) and adult offspring (460).”
Is folic acid good for everyone? (2008, background): “The authors suggested that this “nutritional programming” of childhood features might be related to epigenetic regulation mediated by DNA methylation in a manner similar to the folate-sensitive nutritional programming in animals discussed above (149).”
Epigenetics and the embodiment of race: Developmental origins of US racial disparities in cardiovascular health (2009, background): “Recent experimental studies in animal models demonstrate how epigenetic markings in offspring may respond to maternal factors like diet (Lillycrop et al., 2005) and rearing behavior (Weaver et al., 2004).”
Epigenetic gene promoter methylation at birth is associated with child’s later adiposity (2011, background): “Although epigenetic changes can be dynamic, experimental studies have shown that environmental factors acting on the genotype during development relate to epigenetic profile in adulthood (7,15), and there are longitudinal human studies showing that DNA methylation is often stable over time (37).”
Early life events and their consequences for later disease: A life history and evolutionary perspective (2007, background): “The glucocorticoid receptor in the brain and liver appears to be a target of epigenetic regulation by maternal factors (Lillycrop et al., 2005; Weaver et al., 2004).”
Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study (2007, background): “Epigenetic regulation, involving DNA methylation, may be another mechanism of nutritional programming, as demonstrated in animal models [43–45].”