Parallel Pathways for Cross-Modal Memory Retrieval in Drosophila
By Xiaonan Zhang, Qingzhong Ren, Aike Guo. 2013
16 citations recorded by the source corpus.
Memory-retrieval processing of cross-modal sensory preconditioning is vital for understanding the plasticity underlying the interactions between modalities. As part of the sensory preconditioning paradigm, it has been hypothesized that the conditioned response to an unreinforced cue depends on the memory of the reinforced cue via a sensory link between the two cues. To test this hypothesis, we studied cross-modal memory-retrieval processing in a genetically tractable model organism, Drosophila melanogaster. By expressing the dominant temperature-sensitive shibirets1 (shits1) transgene, which blocks synaptic vesicle recycling of specific neural subsets with the Gal4/UAS system at the restrictive temperature, we specifically blocked visual and olfactory memory retrieval, either alone or in combination; memory acquisition remained intact for these modalities. Blocking the memory retrieval of the reinforced olfactory cues did not impair the conditioned response to the unreinforced visual cues or vice versa, in contrast to the canonical memory-retrieval processing of sensory preconditioning. In addition, these conditioned responses can be abolished by blocking the memory retrieval of the two modalities simultaneously. In sum, our results indicated that a conditioned response to an unreinforced cue in cross-modal sensory preconditioning can be recalled through parallel pathways.
Subfields: Cellular and Molecular Neuroscience, Ecology, Genetics
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In Cellular and Molecular Neuroscience
- Yoshinori Aso
- Gerald M. Rubin
- Hiromu Tanimoto
- P. Plaçais
- T. Préat
- Nobuhiro Yamagata
- Toshiharu Ichinose
- M. Nitabach
In Ecology
In Genetics
- Yoshinori Aso
- Gerald M. Rubin
- P. Plaçais
- Hiromu Tanimoto
- T. Préat
- Nobuhiro Yamagata
- Toshiharu Ichinose
- Kristin Branson
Citations in the corpus
- Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “…of the MB output neurons in visual memory The MB has been proposed to play diverse roles in visual behaviors including context generalization and sensory preconditioning between olfactory and visual cues (Liu et al., 1999; Zhang et al., 2013, 2007; Brembs, 2009; van Swinderen et al., 2009).”
- Shared mushroom body circuits underlie visual and olfactory memories in Drosophila (2014, unknown): “The α/β neurons might play more modulatory roles in specific visual memory tasks, such as context generalization, facilitation of operant learning and occasion setting (Liu et al., 1999; Tang and Guo, 2001; Brembs and Wiener, 2006; Brembs, 2009; Zhang et al., 2013).”