A PML-PPARδ pathway for fatty acid oxidation regulates haematopoietic stem cell maintenance

By Keisuke Ito, Arkaitz Carracedo, Dror Weiss, F. Arai, U. Ala, D. Avigan, Z. Schafer, R. Evans, T. Suda, Chih‐Hao Lee and 1 more. Nature Medicine, 2012

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Stem-cell function is an exquisitely regulated process. Thus far, the contribution of metabolic cues to stem-cell function has not been well understood. Here we identify a previously unknown promyelocytic leukemia (PML)–peroxisome proliferator-activated receptor δ (PPAR-δ)–fatty-acid oxidation (FAO) pathway for the maintenance of hematopoietic stem cells (HSCs). We have found that loss of PPAR-δ or inhibition of mitochondrial FAO induces loss of HSC maintenance, whereas treatment with PPAR-δ agonists improved HSC maintenance. PML exerts its essential role in HSC maintenance through regulation of PPAR signaling and FAO. Mechanistically, the PML–PPAR-δ–FAO pathway controls the asymmetric division of HSCs. Deletion of Ppard or Pml as well as inhibition of FAO results in the symmetric commitment of HSC daughter cells, whereas PPAR-δ activation increased asymmetric cell division. Thus, our findings identify a metabolic switch for the control of HSC cell fate with potential therapeutic implications.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/70c9e53610ec77f2bffdd6fecbed84b3cf8c89c9

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In Immunology

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Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity (2018, background): “Since cell metabolism in LT-HSCs is linked to LT-HSC maintenance (Ito et al., 2012; Murphy et al., 2011; Takubo et al., 2013; Wang et al., 2014; Yvan-Charvet et al., 2010), we investigated whether the b-glucan-induced metabolic changes in LT-HSCs were sustained also after 5-FU administration,…”