Chronic stress and age-related increases in the proinflammatory cytokine IL-6

By J. Kiecolt-Glaser, Kristopher J Preacher, R. Maccallum, C. Atkinson, W. Malarkey, R. Glaser. Proceedings of the National Academy of Sciences of the United States of America, 2003

1,281 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, General Health Professions

View Paper: https://www.semanticscholar.org/paper/709086872ec8bc44bab86a42b8af47fd4fc169d4

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Citations in the corpus

Effect of Compassion Meditation on Neuroendocrine, Innate Immune and Behavioral Responses to Psychosocial Stress (2008, background): “…data demonstrate that naturalistic life stress increases IL-6 and that elevated plasma levels of IL-6 are a risk factor for the development and/or progression of a number of disease states (Ridker, 2000; Pradhan et al., 2001; Kiecolt-Glaser et al., 2003; Perry et al., 2007; Steptoe et al., 2007).”
Health psychology: developing biologically plausible models linking the social world and physical health. (2009, background): “Whereas chronic stress can suppress several aspects of adaptive immune function, it also appears to induce a chronic and systemic state of mild inflammation (Kiecolt-Glaser et al. 2003, Miller et al. 2008, Ranjit et al. 2007a).”
Family Caregiving for Older Adults (2020, background): “…M anuscript Disease Risk Scores in dementia caregivers, as well as proinflammatory changes and accelerated aging of the immune system (i.e., telomere erosion) (Allen et al. 2017, Damjanovic et al. 2007, Haley et al. 2010, Kiecolt-Glaser et al. 2003, Mausbach et al. 2007, von Känel et al. 2008).”
THE SHORT-TERM IMPACT OF UNCONDITIONAL CASH TRANSFERS TO THE POOR: EXPERIMENTAL EVIDENCE FROM KENYA (2016, neutral): “Chronic elevations of cortisol have the opposite effect, leading to permanent mild elevations of cytokine levels (Kiecolt-Glaser et al. 2003).”
Exposure to a Social Stressor Alters the Structure of the Intestinal Microbiota: Implications for Stressor-Induced Immunomodulation (2010, background): “For example, prolonged stressors, such as the stress of caring for a spouse with dementia or chronic work stress, are associated with elevated cytokines like IL-6 and TNF-a (Hemingway et al., 2003; Kiecolt-Glaser et al., 2003).”
Informal caregiving and its impact on health: a reappraisal from population-based studies. (2015, background): “…specifically restricted to dementia caregivers have reported higher inflammatory burden and other biomarkers of poorer health in these caregivers compared with various noncaregiving comparison groups (Gouin et al. 2012; Kiecolt-Glaser et al., 2003; Lovell & Wetherell, 2011; von Känel et al., 2006).”
Hostile marital interactions, proinflammatory cytokine production, and wound healing. (2005, methodology): “Plasma IL-6 and tumor necrosis factor (TNF- ) levels and chamber-fluid IL-6, TNF- , and IL-1 levels were assayed using Quantikine High Sensitivity Immunoassay kits (R&D Systems, Minneapolis, Minn), per kit instructions, as described elsewhere.(47) Samples were run undiluted in duplicate, and all sam”
Household Response to Income Changes: Evidence from an Unconditional Cash Transfer Program in Kenya ∗ (2013, background): “Chronic elevations of cortisol, however, have the opposite effect, leading to permanent mild elevations of cytokine levels (Kiecolt-Glaser et al. 2003).”
Adverse childhood experiences, allostasis, allostatic load, and age-related disease. (2012, background): “Despite the elevated cortisol levels, some maltreated children also exhibit elevated inflammation levels, similar to changes described in adults exposed to psychosocial stressors [27,93].”
Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system (2005, background): “Furthermore, inflammatory cytokines have also been linked to depressive withdrawal from normal activities (55).”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “355, 466, 565), 2) chronic stress increases its production in aged patients (272), 3) IL-6 expression is increased in the HF of senescence-accelerated mice (539), and 4) hippocampal neurogenesis is reduced in adult transgenic mice with chronic IL-6 production (552) or after administration of bacteri”