Muscles, exercise and obesity: skeletal muscle as a secretory organ

By B. K. Pedersen, M. Febbraio. Nature Reviews Endocrinology, 2012

2,698 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/7053d2f849635807b22a4df75d203dcd876ce49b

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Citations in the corpus

FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine (2013, neutral): “months [1,22–27].”
Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. (2016, positive): “Plasma IL-6 increases dramatically during exercise due to release from contractingmuscles andmight be the additional exercise factor, involved in tumor homing (Pedersen and Febbraio, 2012).”
Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “The role of myokines has previously been reviewed (7, 11-37), identifying more than 650 myokines (38).”
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise (2012, background): “In this context, the muscle tissue has recently been recognized as an endocrine organ that releases a variety of cytokines, termed myokines, which regulate several physiological andmetabolic pathways [6].”
Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. (2013, background): “Otherwise, some myokines such as IL-6 and IL-15, mainly produced after physical exercise, display beneficial effects on metabolism interacting with the adipose tissue (5, 6).”
Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. (2018, positive): “Perhaps a more powerful determinant of IL-6 production levels is the depletion of glycogen stored in muscle tissue (Pedersen & Febbraio, 2012).”
Exercise metabolism and the molecular regulation of skeletal muscle adaptation. (2013, background): “In turn, these proteins exert wider metabolic effects on organs including fat, liver, gut, and pancreas and act locally on muscle in an autocrine/paracrine manner (Pedersen and Febbraio, 2012).”
Homeostasis, Inflammation, and Disease Susceptibility (2015, neutral): “, 2011); the myokines IL-6 (Pedersen and Febbraio, 2012) and meteorin-like (Rao et al.”