MicroRNAs modulate the angiogenic properties of HUVECs.

By L. Poliseno, Andrea Tuccoli, L. Mariani, Monica Evangelista, L. Citti, K. Woods, A. Mercatanti, Scott M. Hammond, G. Rainaldi. Blood, 2006

793 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6fa83c1a1983458fd664c9a4a821518a18a2b6d2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. (2007, background): “While this association has not been previously demonstrated in gastrointestinal tract tumors, miR-221 expression is important in thyroid cancer and is suggested to play a role in angiogenesis.(18,19) Working together with miR-222, which was also found to be overexpressed in the pancreatic cancers we”
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, neutral): “In endothelial cells, miR-221 and miR-222 repress proliferative and angiogenetic properties of c-Kit, while hypoxic signals reduce expressions of miR-16, miR-15b, miR-20a and miR-20b, directly targeting VEGF, and supporting the angiogenic process (Poliseno et al, 2006).”
The Role of MicroRNAs in Human Diseases (2010, background): “In recent studies (57 - 59) the mirRNA expression pattern (known for its tissue and cell type specificity) in endothelial cells has been demonstrated to include let-7b, miR-16, miR-21, miR-23a, miR-29, miR-100, miR-221, and miR-222.”
MicroRNA signature predicts survival and relapse in lung cancer. (2008, background): “hsa-miR-221 is another protective microRNA that inhibits erythroleukemic cell growth and angiogenesis via kit receptor downmodulation, suggesting a possible role for miR-221 at least as a modulator of the formation of vessels in tumor microenvironment (Felli et al., 2005; Poliseno et al., 2006).”
Role of microRNAs in vascular diseases, inflammation, and angiogenesis. (2008, background): “Thus, transfection of endothelial cells with miR-221 and miR-222 inhibits tube formation, migration, and wound healing of endothelial cells in vitro.(34) Consistently, another study demonstrated the anti-angiogenic function of miR-221/222 in endothelial cells.”
Genomic profiling of microRNA and mRNA reveals deregulated microRNA expression in prostate cancer (2008, background): “However, this cluster also inhibits the oncogene c-Kit and angiogenesis (50).”