Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis

By Tingfen Li, Yongmin Yan, Bingying Wang, Hui Qian, Xu Zhang, Li Shen, Mei Wang, Ying Zhou, Wei Zhu, Wei Li and 1 more. Stem Cells and Development, 2013

807 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6f88cef28b66a1246a9b36d0d72c50658cdb5a85

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. X. Breakefield
2. S. El Andaloussi
3. P. Vader
4. Jan Lötvall
5. Edit I. Buzás
6. M. Qasim
7. Muniyandi Jeyaraj
8. Sangiliyandi Gurunathan

In Genetics

1. Lorraine O'Driscoll
2. P. Vader
3. B. W. van Balkom

In Molecular Biology

1. X. Breakefield
2. C. Théry
3. S. El Andaloussi
4. P. Vader
5. Jan Lötvall
6. Muniyandi Jeyaraj
7. M. Qasim
8. Sangiliyandi Gurunathan

Citations in the corpus

• Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Human umbilical cord MSC-derived EVs protect against acute renal injury and liver fibrosis [273,274].”
• Advances in therapeutic applications of extracellular vesicles (2019, background): “EVs derived from MSCs have been reported to have therapeutic potential in preclinical studies in diverse tissues and indications, including the treatment of diseases and regenerative medicine targeting the lungs (29–31), kidney (32–34), liver (35, 36), central nervous system (37–39), cartilage (40–4”
• Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases (2019, background): “MSC-Exos completely reversed spindle-shaped morphology and abrogated expression of EMT-associated markers in HL7702 human hepatocytes that underwent EMT after treatment with recombinant TGF-β1 [44].”
• Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine (2018, background): “They demonstrated that transplantation of MSC-EVs could improve liver fibrosis and protect hepatocytes via suppression of epithelial-to-mesenchymal transition and inactivation of the TGF-β1/Smad 2 pathway [39].”
• Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper (2015, background): “After demonstrating that human liver stem cell derived EVs accelerated hepatic regeneration in hepatectomized rats (113), MSC-EVs were successfully tested for their capability to alleviate drug-induced liver injury (114,115).”
• Mechanisms of mesenchymal stem/stromal cell function (2016, neutral): “duce liver fibrosis [169].”