Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men

By C. Desouza, L. F. Shapiro, Christopher M. Clevenger, F. Dinenno, K. Monahan, Hirofumi Tanaka, D. Seals. Circulation, 2000

965 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli. (2017, background): “Exercise training in middle-aged subjects improved forearm resistance vessel endothelial function (65) and NO bioavailability (281).”
Exercise is the real polypill. (2013, background): “In previously sedentary middleaged and older healthy men, regular aerobic exercise can prevent the age-associated loss in endothelium-dependent vasodilation (as assessed by vasodilatory response to acetylcholine) and restore this variable to levels similar to those of young adults (103).”
Effect of exercise training on endothelium‐derived nitric oxide function in humans (2004, background): “However, studies that have identified improved stimulated endothelium-dependent vasodilatation have prescribed at least 10 weeks of training in normal subjects (Clarkson et al. 1999; DeSouza et al. 2000).”
The clinical implications of endothelial dysfunction. (2003, background): “Exercise is an important lifestyle factor that reduces cardiovascular risk (44), and exercise has been repeatedly shown to improve endothelial vasomotor function in healthy subjects (45,46) and in disease states including hypertension (47), congestive heart failure (48), and CAD (49).”