Genomic analysis of metastasis reveals an essential role for RhoC

By E. Clark, Todd R. Golub, Eric S. Lander, R. Hynes. Nature, 2000

1,522 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6f2738aac7c8579d031fc3bb06888fb7bc29757a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. P. Chiarugi
2. M. Parri
3. G. Semenza
4. F. M. Vega
5. C. Der
6. A. Ridley
7. C. V. Dang
8. Yibin Kang

In Immunology and Allergy

1. A. Ridley
2. P. Chiarugi
3. Meenhard Herlyn
4. T. Bogenrieder

In Molecular Biology

1. J. Massagué
2. C. V. Dang
3. G. Semenza
4. A. Moustakas
5. C. Heldin
6. Ping Gao
7. B. Spiegelman
8. Yibin Kang

Citations in the corpus

• Rac and Rho GTPases in cancer cell motility control (2010, background): “RhoC High protein levels, high signalling activity Melanoma metastases [119], breast [121], squamous cell (SCC) [122], pancreas [123], liver [124], ovarian [110], head and neck [120], prostate [126], non-small cell lung (NSCLC) [127], gastric cancer [125]”
• Targeting mitochondrial glutaminase activity inhibits oncogenic transformation (2010, positive): “In particular, two members of the family, RhoA and RhoC, have been linked to the progression of malignancy, i.e., poorly differentiated pheno- types, local invasiveness, and metastasis (Kleer et al., 2002; Clark et al., 2000; Burbelo et al., 2004; Valastyan et al., 2009).”
• Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. (2003, background): “associated with tumor invasion is fibronectin 1 (38, 39).”
• Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. (2003, background): “…by animal models in which poorly metastatic cell lines can spawn highlyProstate cancers are known to metastasize; however, so far very little is known regarding the mechanisms governing prostate metastatic variants after multiple rounds of selection (Clark et al., 2000; Fidler and Kripke, 1977).”
• TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. (2005, methodology): “Combining this information with systematic screens of PubMed and cross-referencing with microarray data from studies of breast cancer, epithelial invasiveness, and metastasis (Clark et al., 2000; Ryu et al., 2001; van’t Veer et al., 2002; Jechlinger et al., 2003; Kang et al., 2003b), we selected a g”