Neurobehavioural effects of developmental toxicity
By P. Grandjean, Philip J. Landrigan. Lancet Neurology, 2014
1,596 citations recorded by the source corpus.
Neurodevelopmental disabilities, including autism, attention-deficit hyperactivity disorder, dyslexia, and other cognitive impairments, affect millions of children worldwide, and some diagnoses seem to be increasing in frequency. Industrial chemicals that injure the developing brain are among the known causes for this rise in prevalence. In 2006, we did a systematic review and identified five industrial chemicals as developmental neurotoxicants: lead, methylmercury, polychlorinated biphenyls, arsenic, and toluene. Since 2006, epidemiological studies have documented six additional developmental neurotoxicants—manganese, fluoride, chlorpyrifos, dichlorodiphenyltrichloroethane, tetrachloroethylene, and the polybrominated diphenyl ethers. We postulate that even more neurotoxicants remain undiscovered. To control the pandemic of developmental neurotoxicity, we propose a global prevention strategy. Untested chemicals should not be presumed to be safe to brain development, and chemicals in existing use and all new chemicals must therefore be tested for developmental neurotoxicity. To coordinate these efforts and to accelerate translation of science into prevention, we propose the urgent formation of a new international clearinghouse.
Subfields: Developmental Neuroscience, Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/6e9876806a4f48adb1c7aed6dded69ab03071fdd
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Citations in the corpus
- Aquatic food security: insights into challenges and solutions from an analysis of interactions between fisheries, aquaculture, food safety, human health, fish and human welfare, economy and environment (2016, background): “Human dietary exposure to bioaccumulative pollutants including methylmercury, polychlorinated biphenyls and emerging contaminants can pose risks to health; as many of these chemicals act as neurotoxicants (Nesheim and Yaktine 2007; Sunderland 2007; Grandjean and Landrigan 2014).”
- The Changing Epidemiology of Autism Spectrum Disorders (2016, background): “However, EDCs are of concern because they interfere with the activity of hormones critical in neurodevelopment (164), may interfere with immune system activity (79), and have been associated with a range of other neurodevelopmental endpoints (70).”
- Human pluripotent stem cell-derived neural constructs for predicting neural toxicity (2015, background): “The human brain is particularly sensitive to toxic insults during development and early childhood (8), and there is growing concern that exposure to environmental chemicals may be linked to the rising incidence of neurodevelopmental disorders worldwide (4).”
- Measuring environmental inequality (2016, background): “6 including autism, attention-deficit hyperactivity disorder, dyslexia and other cognitive impairments (Grandjean and Landrigan 2014).”
- Green spaces and cognitive development in primary schoolchildren (2015, background): “The brain develops steadily during prenatal and early postnatal periods, which are considered as the most vulnerable windows for effects of environmental exposures (11).”