Coordinated histone modifications mediated by a CtBP co-repressor complex

By Yang Shi, J. Sawada, Guangchao Sui, E. Affar, J. Whetstine, F. Lan, Hidesato Ogawa, M. P. Luke, Y. Nakatani. Nature, 2003

823 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6e5baa84ff552057a325e539dd346839d6f523be

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Yi Zhang
2. A. Cano
3. Yang Shi
4. E. Li
5. H. Peinado
6. Maite Huarte
7. E. Seto
8. K. Willert

In Molecular Biology

1. Yang Shi
2. Yi Zhang
3. J. Whetstine
4. Y. Tsukada
5. Paul Tempst
6. H. Erdjument‐Bromage
7. A. Cano
8. H. Peinado

Citations in the corpus

• N6-methyladenosine Modulates Messenger RNA Translation Efficiency (2015, neutral): “identification We followed the previously reported protocol (Shi et al., 2003).”
• Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. (2005, background): “2002), CtBP1 (Shi et al. 2003), and CDB/cut (Nishio and Walsh 2004), contained not only G9a but also Eu-HMTase1.”
• Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (2006, background): “…methylation is Cell 125, 467–481, May 5, 2006 ª2006 Elsevier Inc. 467 considered a repressive mark for euchromatic genes (Nielsen et al., 2001; Shi et al., 2003) and is also one of the landmark modifications associated with heterochromatin (Nakayama et al., 2001; Peters et al., 2002; Rea et…”
• Wnt signaling: is the party in the nucleus? (2006, background): “CtBP complexes also contain CoREST, G9A, EuHMT HDAC1/2, and LSD1 (KIAA0601/NPAO), among other proteins (Shi et al. 2003), and binding of CtBP is correlated with the loss of histone modifications, including H3K4Me3, at the Ecadherin gene in vivo (Shi et al. 2003; Wysocka et al. 2005b).”
• RBP-Jκ/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes (2005, background): “In fact, we demonstrated that CtIP colocalizes with wild-type SHARP(12-3664) in the nucleus and SHARP lacking a nuclear localization signal (aa 2002 to 3664) in the cytoplasm (Fig.”
• Transcriptional regulation of cadherins during development and carcinogenesis. (2004, background): “…co-repressor complex containing different methylase and HDAC activities, as well as the δEF1 and SIP1 factors, and which is functionally active on E-cadherin promoter regulation (Shi et al., 2003), strongly support the participation of CtBP complexes in down-regulating E-cadherin expression (Fig.”
• A Nurr1/CoREST transrepression pathway attenuates neurotoxic inflammation in activated microglia and astrocytes (2009, neutral): “CoREST assembles many chromatin-modifying enzymes, including histone methyltransferase G9a, histone demethylase, lysine-specific demethylase (LSD1) and histone deacetylase (HDAC) 1 and 2 (Shi et al., 2003).”