Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin

By M. Péterfy, J. Phan, P. Xu, K. Reue. Nature Genetics, 2001

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Lipoprotein lipase: from gene to obesity. (2009, background): “The gene that is responsible for the fld mutation is lipin1, which encodes a novel nuclear protein that is expressed in high levels in adipose tissue and skeletal muscle (195).”
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression (2004, background): “Included in this group is the newly discovered gene lipin, which, when mutated, results in lipodystrophy (64).”
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “Loss of lipin 1 function leads to hepatic steatosis and hypertriglyceridemia, but reduced adipose tissue [Peterfy et al., 2001].”