5-Fluorouracil: mechanisms of action and clinical strategies

By D. Longley, D. Harkin, P. Johnston. Nature Reviews. Cancer, 2003

5,134 citations recorded by the source corpus.

Subfields: Oncology, Pathology and Forensic Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/6df25c2a166dd496d8239fdba043f9f65d5ed53a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. Stephen J. Elledge
2. P. Johnston
3. Shufeng Zhou
4. Jun-Ping Liu
5. Ji Luo
6. B. Chowbay
7. D. Longley
8. N. Solimini

In Pathology and Forensic Medicine

1. Ji Luo
2. Stephen J. Elledge
3. N. Solimini

In Surgery

1. Ji Luo
2. Stephen J. Elledge
3. N. Solimini

Citations in the corpus

• Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009, positive): “…and Scherle, 2006 5-fluorouracil (small molecule) DNA NOA Inhibits pyrimidine metabolism, incorporation in to DNA and RNA causes cell-cycle arrest Longley et al., 2003 ABT-737, ABT-263 (small molecule) BCL-XL, BCL-2 OA Bind to the BH3 pocket of Bcl-XL and inhibit its antiapoptotic function…”
• Apoptosis and Molecular Targeting Therapy in Cancer (2014, background): “Thus, TS expression acted as a key determinant of 5-FU sensitivity [62] while in vitro studies have validated the association between TS expression and apoptosis 5-FU [63, 64] while the improved response rates of 5-FU-based chemotherapy were observed in patients with low tumour TS expression [65, 66”
• 5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies (2008, background): “Leucovorin (LV), which enters the cell via the reduced folate carriers and is anabolized to CH2THF, increases the intracellular CH2THF pool, thereby enhancing TS inhibition by FdUMP [30].”
• Regulation of mammalian nucleotide metabolism and biosynthesis (2015, background): “Despite its functional importance, nucleotide metabolism and cell cycle control have received much less attention than genomics and functional genomics, although there have been multiple metabolic targets derived from the relevant processes for human disease therapy, such as the antimetabolites MTX ”
• Polymorphism of human cytochrome P450 enzymes and its clinical impact (2009, background): “5-FU is converted to three main active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP), and fluorouridine triphosphate (FUTP) (Longley et al., 2003).”
• Molecular mechanisms of drug resistance (2005, background): “Numerous pre-clinical studies have demonstrated that TS expression is a key determinant of 5-FU sensitivity [41].”
• 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. (2010, background): “incorporate in RNA and DNA and inhibit TS, is a cytotoxic agent widely used in the treatment of colorectal and breast cancers, as well as cancers of the aerodigestive tract (21).”